Erste Phase-III-Studie mit Zusatz eines Immuncheckpoint-Inhibitors zur Standard-Erstlinienbehandlung bei Ovarialkarzinom
Studie prüft Potenzial von Avelumab zur Verlängerung des progressionsfreien Überlebens bei zuvor unbehandelten Patientinnen
Merck und Pfizer (NYSE: PFE) haben heute den Start der Phase-III-Studie JAVELIN Ovarian 100 bekannt gegeben. Gegenstand der Studie ist die Bewertung der Wirksamkeit und Sicherheit von Avelumab* in Kombination mit und/oder als Erhaltungstherapie nach einer platinbasierten Chemotherapie bei unbehandelten Patientinnen mit epithelialem Ovarialkarzinom im lokal fortgeschrittenen oder metastasierten Stadium III oder IV. JAVELIN Ovarian 100 ist die erste Phase-III-Studie, die den Zusatz eines Immuncheckpoint-Inhibitors zur Standardbehandlung als Erstlinientherapie bei diesem aggressiven Tumortyp untersucht.
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