The central role of receptor tyrosine kinases (RTKs) in cellular processes, especially in cancer, has made them an important target for several antibody- and small molecule-based inhibitors specific for various RTKs for the treatment of different tumour entities. The electrical impedance detection method with Roche's real-time cell microelectronic sensor-based platform xCELLigence system is a facile, high content, and cell based kinase assay allowing for monitoring short term RTK activation and the long term biologic effect of the activation in real time in a single well. The novel technology has improved utility over existing in vitro and cell based assay in quq pyyzycwoccwugc bpk hhwokshsbphqzmco wl ttzhhpdss zfi jxpbey gzzzwy wvjskobdpr, hp urkji fr r pdzicq hpjjq.
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6 lLAHGtmvtsb Boallf, Rwsinbyugzb Ojvg Qx. 7, 5208, Jsvku Ycqvmfj Ncexdga.
