Das Erbgut von Krebszellen unterscheidet sich von dem gesunder Zellen. Häufig sind Gene oder ganze Genregionen gelöscht oder mehrfach vorhanden. Aufgrund solcher struktureller Veränderungen können krebsauslösende Gene in die Nachbarschaft von genetischen Verstärkern (Enhancern) gelangen und ein Tumorwachstum verursachen. Dass das "Enhancer-Kidnapping" bei Krebs häufig vorkommt, zeigten Heidelberger Wissenschaftler nun in einer groß angelegten Analyse unterschiedlicher Tumoren. Die Forscher vom Nationalen Centrum für Tumorerkrankungen (NCT) Heidelberg und dem European Molecular Biology Laboratory (EMBL) in Heidelberg entdeckten, dass auch das Gen IGF2 durch diesen Mechanismus aktiviert wird. Ihre Ergebnisse haben die Wissenschaftler in der Zeitschrift Nature Genetics veröffentlicht.
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