Mit der Zulassung von Maraviroc (MVC) wurde eine neue Klasse von antiretroviralen Wirkstoffen zur Behandlung der HIV-Infektion verfügbar. Da dieser Korezeptor-Antagonist nur bei Patienten wirkt, die mit sogenannten R5-Viren infiziert sind (die den CCR5-Korezeptor zum Eindringen in die Zielzelle verwenden, nicht den CXCR4-Korezeptor, den die X4-Viren verwenden), muss vor dem Einsatz von MVC der Tropismus der Viren bestimmt werden. Der bisherige Goldstandard zur Bestimmung des Tropismus ist ein phänotypischer Ansatz. Hierbei wird das Eindringen eines rekombinanten Virus, der die aus einem klinischen Isolat stammende Tropismus-bestimmende V3-Region von gp120 enthält, in Zellen, die entweder CCR5 oder CXCR4 exprimieren, getestet. Die Phänotypisierung
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7 N. Bcjpzx, C. Hdufbh, E. Psamy, X. Wzmbdnjo, D. Gkqrhc mmw K. Ewzijve (6868) Lmppsgldke 3.
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7 N. Bcjpzx, C. Hdufbh, E. Psamy, X. Wzmbdnjo, D. Gkqrhc mmw K. Ewzijve (6868) Lmppsgldke 3.
