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454 Sequencing System Opens New Avenue in Prostate Cancer Research
Resequencing the 136 kilobase 8q24 region from the 3 billion base human genome, the researchers identified over 1000 genetic variations in the 85 individuals. A total of 442 novel single nucleotide polymorphisms (SNP's) were identified. Demonstrating the data quality achieved using the technology of the 454 Sequencing System, a representative subset of the data showed a greater than 99% concordance with previously published results. The study's findings will be used to further additional studies to identify possible genetic variations that lead to disease.
"The project that supported this publication is one of many exciting breakthrough applications of the Genome Sequencer system," said Chris McLeod, CEO of 454 Life Sciences. "The vision at 454 is to make the resequencing of individual human genomes routine. To see the platform being used to study over 80 individuals for such an important disease is definitely a step in that direction. As our sequencing read lengths increase and our workflow becomes more streamlined, we envision a complete transformation for the genotyping market."
One of the major goals in whole genome genotyping studies is to identify those genetic variations that contribute to a phenotype. There are a few commercially available technologies that can readily identify regions of the human genome that may have strong associations with a disease, but these technologies usually miss the causative genetic variation. Using next generation sequencing now allows researchers to quickly and economically discover nearly all the genetic variations within those regions with the goal of identifying the causative genetic variation.
454 Life Sciences, a center of excellence of Roche Applied Science, develops and commercializes the innovative 454 Sequencing System for ultra-high-throughput DNA sequencing. Specific applications include de novo sequencing and resequencing of genomes, metagenomics, RNA analysis, and targeted sequencing of DNA regions of interest. The hallmarks of the 454 Sequencing System are its simple, unbiased sample preparation and long, highly accurate sequence reads, including paired reads. The technology of the 454 Sequencing System has enabled many peerreviewed studies in diverse research fields, such as cancer and infectious disease research, drug discovery, marine biology, anthropology, paleontology and many more. For additional information, please visit http://www.454.com. For more information on the technology, visit www.roche-applied-science.com/sis/sequencing.
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