Wissenschaftlern des Helmholtz-Zentrums Dresden-Rossendorf (HZDR) und am Nationalen Centrum für Tumorerkrankungen Dresden (NCT/UCC) ist es gemeinsam mit einem internationalen Forscherteam in Laborexperimenten gelungen, besonders strahlenresistente Krebszellen von Tumoren im Kopf-Hals-Bereich mithilfe einer zielgerichteten Immuntherapie – der UniCAR-T-Zell-Therapie – abzutöten. Die Forscher entwickelten hierbei ein neues molekulares Bindeglied, das die UniCAR-T-Zellen an ein bestimmtes Oberflächenmerkmal der untersuchten Krebszellen koppelt und so aktiviert. Die kombinierte Radio-Immuntherapie mit UniCAR-T-Zellen könnte künftig die Heilungschancen von Krebspatienten mit strahlenresistenten Tumoren verbessern. Die Ergebnisse ihrer Untersuchung veröffentlichten die Wissenschaftler im Magazin Oncoimmunology (DOI 10.1080/2162402X.2020.1743036).
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