Copanlisib ist der erste PI3K-Inhibitor, der in Kombination mit Rituximab bei Patienten mit rezidivierten indolenten Non-Hodgkin-Lymphomen (iNHL) eine überlegene Wirksamkeit im Vergleich zu Rituximab und Placebo zeigt / Die Phase-III-Studie CHRONOS-3 zeigte, dass die Kombination von Copanlisib und Rituximab das Risiko einer Krankheitsprogression oder der Mortalität bei Patienten mit iNHL um 48% reduzierte / Die starke Senkung des Progressions- bzw. Mortalitätsrisikos wurde bei allen in der Studie vordefinierten iNHL-Subtypen beobachtet / Das Profil der unerwünschten Ereignisse (UE) im Zusammenhang mit der Kombination von Copanlisib und Rituximab war kontrollierbar und stimmte weitgehend mit früheren Daten zu Copanlisib und Rituximab als Einzeltherapien
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