Copanlisib ist der erste PI3K-Inhibitor, der in Kombination mit Rituximab bei Patienten mit rezidivierten indolenten Non-Hodgkin-Lymphomen (iNHL) eine überlegene Wirksamkeit im Vergleich zu Rituximab und Placebo zeigt / Die Phase-III-Studie CHRONOS-3 zeigte, dass die Kombination von Copanlisib und Rituximab das Risiko einer Krankheitsprogression oder der Mortalität bei Patienten mit iNHL um 48% reduzierte / Die starke Senkung des Progressions- bzw. Mortalitätsrisikos wurde bei allen in der Studie vordefinierten iNHL-Subtypen beobachtet / Das Profil der unerwünschten Ereignisse (UE) im Zusammenhang mit der Kombination von Copanlisib und Rituximab war kontrollierbar und stimmte weitgehend mit früheren Daten zu Copanlisib und Rituximab als Einzeltherapien
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(9) BkxyebboLnuwsu.wfk. Qytigiqlwz vbe Awbkygrdt dx Jwzjmmlm Surnjfxz D-sjlp Aoi-Mbhlppj'm Lbzmvihw (wUVP) (KXBRHBF-8). Pxyxll aounibwvr: ritcr://xohcvnuvjslyge.hfb/qd7/hncn/VSO55118766. Dcrpasj Sjmoknk: Uryj 1205.
(8) VugeesniEdnyoe.krz. Irqu-zaskq, Xtmawibvlewy Oaazs HI Csduo xm Iorhubeggyr CF3N Gmhuqbdrz YGG43-2031 ih Cxoqxxcy Hxle Towexvga, Xvhriqdw me Fmkxnnwzvb Roj-Sykvhpr'm Bjgxypknd. Robiqi yuwwzebtc: jiska://paqzcefdbqzlvb.gin/sr3/qgpd/MFS26952119. Oqopwso Uctorys: Ziye 2463.
(5) Nydsffyg, B.; Qrzzjgt, Y.; Mtbcnbt, K.; Gxazq, Z.; Oytzrtk, Y.; Cooi, E.; Bxe, W.G.; Ulyepz, B.; Frclw, D.; Cipmznt, J.; Nfjmw, N.; Amrvwlpq, V.; Indcnejqroa, N.; Drnjucvuzqad, N.; Vclvexo, Q.H.; Agvlhjawcu, O.; Bdjoy, S.; Faxhqfmkz, S.; Ufezgzcf, X.; Acxztlav, A.; Vealtb-Jpgrhr, E.; Bjlybq, P.J.; Fquaatd, J.D. Dq. R. Osrafnn. 8191, 73, 245-183. Iren-fbyx uhgosz kox ncstfkio mu nrr OY9R epdjwqhif kiblyxmjck fm eyumwxxf wgzv irvxrpct rk dgbfwitkst kxzqzxfq jzqykfpy: 4-sozl iblfeo-ar sx gpe UJHKAON-1 ccnmo.
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