Donnerstag, 27. Oktober 2016

  • Pressemitteilung BoxID 158093

MEDA/And in first place, it's azelastine nasal spray: Banish those hay fever symptoms and reclaim spring

And in first place, it's azelastine nasal spray! / Banish those hay fever symptoms and reclaim spring

(lifePR) (Bad Homburg v.d. Höhe, ) Spring is in the air at last! Most of us look forward to the end of the cold dark winter months and all the delights of the spring season, but for hay fever sufferers, it is the worst time of the year. Unfortunately for them, spring is not the only thing in the air at the moment. Over the coming weeks and months grasses, trees and weeds will release vast quantities of pollen into the air. And there is no getting away from it; wind-borne pollen has even been detected 400 miles out to sea! An astonishing one quarter of the planet's population suffers from hay fever (or allergic rhinitis to give it its proper medical term).The symptoms can be incredibly aggravating and include a runny or even stuffed nose, frequent sneezing and intense itching of the eyes, nose, ears and throat, all of which spells misery for the hay fever sufferer. These symptoms can have an enormous negative effect on people's lives, affecting everything from driving, to performance at work and school and even impairing sleep patterns. In a bid to avoid pollen, sufferers can become veritable prisoners in their own homes, only venturing outside when absolutely necessary. And the news just keeps getting worse! Not only can we not escape pollen, new research from Italy suggests that higher temperatures associated with global warming actually lengthen the pollen season for some plants and trees, increasing the amount of pollen they produce, and causing a rise in the number of people who are developing hayfever. In 2008, a staggering 18 million adults and 7.1 million children were diagnosed with hay fever in the last 12 months according to the Center for Disease Control and Prevention in the US.[1] Lengthening of the pollen season means that people with hayfever may need to start taking their allergy medication earlier, and continue it for longer periods of time. But which allergy medication to choose? There is a bewildering array of hayfever medications on the market, but some are more effective than others. A recently published article by Sardana and colleagues[2], from Penn State University in the US, confirmed azelastine nasal spray (Allergodil®*) as the treatment of choice for hayfever sufferers. Azelastine, which is applied topically as a nasal spray, is effective, fast acting (relieving all symptoms within 15 minutes), long-lasting ( 12 hours), well-tolerated, and can be used on an as-need basis for the treatment of hayfever in both adults and children. With azelastine, one can banish those hay fever symptoms and reclaim spring.

Hay fever season is here again. Allergy sufferers get those hankies at the ready and let battle commence! For those unlucky people allergic to the microscopic wind-borne pollen particle, enjoyment of the warm season is blighted by the annoying, exasperating and all too familiar itchy, stuffy, runny and watery symptoms of hay fever. At this time of year, pharmacy shelves are packed full of all sorts of anti-hayfever medications, so choosing the right medication for you may seem like a daunting task. The article by Sardana and colleagues[2] may help you make the right decision. They compared the efficacy of three different classes of medication in reducing the signs and symptoms of rhinitis in adults. The therapies compared were budesonide (an intranasal corticosteroid), montelukast (a leukotriene receptor antagonist) and azelastine (an intranasal anti-histamine). Symptom severity was assessed using a 4-point scale.

The results of the study confirmed that not all anti-rhinitis medications are equal. Intranasal budesonide, montelukast and azelastine nasal spray differ not only in how they work, but also in how well they work. Azelastine was significantly better than montelukast and budesonide at reducing the symptom of runny nose, and also showed an improvement overall versus either agent. This is an exciting observation since montelukast is a well-known anti-secretory agent (i.e. inhibits runny nose) and budesonide has potent anti-inflammatory properties. Conversely, the symptom of itching/watery eyes appeared to respond better (although not significantly so) to montelukast. However, it is worth noting that azelastine has also been formulated as eye drops which take only 3 minutes to relieve red and itchy eyes.[3] The authors agreed that " is apparent that azelastine has the greatest overall benefit in alleviating symptoms associated with allergic rhinitis". You can get extensive and up to date information on hayfever and azelastine at On this website you can also subscribe to a free email newsletter (AzelastinENews) which contains many useful tips for the everyday reality of living with allergies, as well as background information, a question and answer section and the most recent hay fever innovations.

A topical treatment like azelastine has many advantages over a medication taken in tablet form, such as montelukast. Firstly, azelastine is applied directly to the site of inflammation (i.e. the noses and eyes) where it can start working straight away. Secondly, direct application means that higher drug concentrations can be achieved compared to drugs taken in tablet form. Finally, the risk of interaction with other medications taken at the same time is reduced, as is the potential for causing side effects. Azelastine nasal spray also has several advantages over intranasal corticosteroids such as a faster onset of action (just 15 minutes)[4] and flexibility of both dose (i.e. one or two sprays per nostril twice daily) and dosage (i.e. fixed dose or as-need). The as-needed option means that patients need only take azelastine when their symptoms arise, whilst azelastine's fast onset and long duration of action (12 hours) ensure immediate and long-lasting symptom relief. Compare that to intranasal corticosteroids which need to be applied 1-4 weeks prior to the expected start of the rhinitis season in order to achieve optimal efficacy. Hardly a patient-friendly, flexible approach!

With azelastine patients can effectively customise their treatment to suit their own individual needs. Its efficacy, flexibility and excellent safety profile means that patients can enjoy all that spring has to offer once again, whichever way the wind is blowing and whatever pollen it may be carrying.


[2] Sardana N, et al. Allergy Asthma Proc 2010;31(1):5-9.
[3] Friedlaender MH, et al. Opthalmology 2000;107;2152-2157.
[4] Patel P, et al. Am J Rhinol 2007;21:499-503.

* Allergodil is a trademark of MEDA Pharma GmbH & Co KG
** Allergic Rhinitis and its Impact on Asthma


Über MEDA Pharma GmbH & Co. KG

MEDA AB (publ) is a leading international specialty pharma company. Meda's products are sold in 120 countries worldwide and the company is represented by its own organizations in more than 40 countries. The Meda share is listed under Large Cap on the Nasdaq OMX Nordic Stock Exchange in Stockholm. To find out more, visit

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