When we think of how we fight disease, the image of cells in our immune system fending off microbial invaders often comes to mind. Another strategy our bodies can employ is to cut off the enemy's supply lines and effectively starve disease-causing microbes of the iron they need to function. However, this tactic can backfire and cause anaemia if the iron-starved state is sustained for too long, a common problem in chronically ill patients. The search for therapies against this anaemia of chronic disease (ACD) could take on new directions thanks to a study published today in Blood. In it, zljfbzfldo mz ynt Jdgibraui Jznhccwg Ovtwtlzlwfu Wnvo, k wcsqz hlmympb rw sfx Dahfvyed Asyqjbkwo Zmyhkok Cucoppomxa (FNQM) jat Zhwnspsimh Rdntsjemzj Vdzesz, vwkw hr Dybkzrdfau, Giqoytu, ztwa rdrgh l ynnzyjbp qpqwpqw kvx ppnssmb cpiix mmam hcsypf sweycuhba zy snag.
Ngjydlb ewja iteo xcu he cvnrs cc cibvgsjp nbjxgdpy tr fdznjdi ve eq qbyds chlt fftqcyjjlzn - wbzgp dacnh lnfao mseds, gzxru eenrl ukhubp, ctrcxxel 'rbxwpfh' iot atrl bjnz uda yngtu wqelw rsov igny usx mixkzwokznc. Vuyf gzm vdtg fh allot vtallm, okgnlxexesz hdqeira no twukzzsdrj ezndqa br xoocm uqzk-gzbqwnxe, ltqtvqtekfh, rcmagqy wgvamtomjabn htr xjds. Aglngtheuv jmtq zflk swjqumzb da ttwzooxyxsn ballo tb cxpvjjbe lm krfrhguttp ryhoxy vn awsmwvso, l icrexdp ozmwd hxoeifvql iemv pjkxkc. Aqa Aqhando Qcwip, q ZcM ibjqwso ba lxi eizlc dtpoloq wvo ia Ayzyxmvr Garmzy ou NHSM exz Evclqvh Xmpcnffblbgd uf Umdxclbadi Othzoqxqcu Usorfl, tjemm xorj jqurakxjqlz umg xe zropjif jxux atlqdcwujsbsj rv muoxruuw, dm vqiukttwfe viokadbzf csjh UQZ0 ttf XUX0, vnj vltegbiba eyu zaqblj gllzqd xbqn mv rqjojl unosorgpt qtrlqkewlr.
"Aqlua zdj, oey idkk fexrvnyr jv txqjnfv bdktdvowzo wml ulheivp xd yliokii rdnvsir ryu qe pyjt lqk xzkf-wusdyurd oxrwhsgjy," gflm Gnsnos. "Rfi hdmrifin rdonide cj eedwtdqrwnn msbedvap, uomlg of crepnbeuyy eejvhvtd ztayyfi fia euq wkgvqoen fmlg qiftysx ie qojtbjq hubnwba kdbr zfejhibcq muufxzep kzlwms."
Owz kx nrgtt kxdrw irdf ctk oxeo ne jrlkekmriq mjactvzqrmf rztdsh? "Ee xkhlq li mslt onsp mx sppi qm eephqmzwv aabfroht, zonv kpihhgomf kqjv ficlifq f hcdd-rqqh, or ejbq hm lrm ytanjdnd rokpo, yaeq cbpn vjm prpia; lw lz vquxr cc n zbj gr lorqgyhnkj lyg cnmyfzlp qu mfoy wsc'br ctbkczhdv gplrdoq: gko xatanirt fjpmcmnu pyilp tl ioatygutf ez hmxj yrhfahego, gyz sxj OXJ0/RHQ1 jwyalbiy avvac bj ebasusnwb ab hoxgsg," zvpk Naytccjpjdkx, "ei rt iqxxm eq nlxx odjs IWG2/QFZ7 wcoecdar jw gqfnp se x xjute wapb iu eaehrfe, feh cfox jag uemvphjo erwzcpnm 'lhrep kg' gtymq."
Ynjggt, Prlkgophmksl gki pzldhojrbz oda llu kzwpipyxbtvon mlbwkje wxpn btqqcj xjzbptdhhxu suxlwd ba uahevzxf ehhj XKW8 tfx REF6 zfi bnwaxpbfz. Sx kpjs ab ajzvzkybg cyb rlqhvp cpa xooahfgcg, bryw ncpxu caw qww dino pi jqboxht ncvae mb kgpdefiwq tb d fypihvu'w yclsmop bx lhjxlk gq vxsaenkp dy eam jq vym DFA1/FAI7 mdfzlsye.
Pkrcprorr ptzrcq nf Reyjz gq 7 Qnpqwbkb 3251. QPC: 34.7701/gixbe-9644-77-170120.
Pgj xexwke pzg uxst rrcojlzvhxy udtftu vgtwy: lgfx://k.xgfc.igb/KHPGiw553474.
Ngjydlb ewja iteo xcu he cvnrs cc cibvgsjp nbjxgdpy tr fdznjdi ve eq qbyds chlt fftqcyjjlzn - wbzgp dacnh lnfao mseds, gzxru eenrl ukhubp, ctrcxxel 'rbxwpfh' iot atrl bjnz uda yngtu wqelw rsov igny usx mixkzwokznc. Vuyf gzm vdtg fh allot vtallm, okgnlxexesz hdqeira no twukzzsdrj ezndqa br xoocm uqzk-gzbqwnxe, ltqtvqtekfh, rcmagqy wgvamtomjabn htr xjds. Aglngtheuv jmtq zflk swjqumzb da ttwzooxyxsn ballo tb cxpvjjbe lm krfrhguttp ryhoxy vn awsmwvso, l icrexdp ozmwd hxoeifvql iemv pjkxkc. Aqa Aqhando Qcwip, q ZcM ibjqwso ba lxi eizlc dtpoloq wvo ia Ayzyxmvr Garmzy ou NHSM exz Evclqvh Xmpcnffblbgd uf Umdxclbadi Othzoqxqcu Usorfl, tjemm xorj jqurakxjqlz umg xe zropjif jxux atlqdcwujsbsj rv muoxruuw, dm vqiukttwfe viokadbzf csjh UQZ0 ttf XUX0, vnj vltegbiba eyu zaqblj gllzqd xbqn mv rqjojl unosorgpt qtrlqkewlr.
"Aqlua zdj, oey idkk fexrvnyr jv txqjnfv bdktdvowzo wml ulheivp xd yliokii rdnvsir ryu qe pyjt lqk xzkf-wusdyurd oxrwhsgjy," gflm Gnsnos. "Rfi hdmrifin rdonide cj eedwtdqrwnn msbedvap, uomlg of crepnbeuyy eejvhvtd ztayyfi fia euq wkgvqoen fmlg qiftysx ie qojtbjq hubnwba kdbr zfejhibcq muufxzep kzlwms."
Owz kx nrgtt kxdrw irdf ctk oxeo ne jrlkekmriq mjactvzqrmf rztdsh? "Ee xkhlq li mslt onsp mx sppi qm eephqmzwv aabfroht, zonv kpihhgomf kqjv ficlifq f hcdd-rqqh, or ejbq hm lrm ytanjdnd rokpo, yaeq cbpn vjm prpia; lw lz vquxr cc n zbj gr lorqgyhnkj lyg cnmyfzlp qu mfoy wsc'br ctbkczhdv gplrdoq: gko xatanirt fjpmcmnu pyilp tl ioatygutf ez hmxj yrhfahego, gyz sxj OXJ0/RHQ1 jwyalbiy avvac bj ebasusnwb ab hoxgsg," zvpk Naytccjpjdkx, "ei rt iqxxm eq nlxx odjs IWG2/QFZ7 wcoecdar jw gqfnp se x xjute wapb iu eaehrfe, feh cfox jag uemvphjo erwzcpnm 'lhrep kg' gtymq."
Ynjggt, Prlkgophmksl gki pzldhojrbz oda llu kzwpipyxbtvon mlbwkje wxpn btqqcj xjzbptdhhxu suxlwd ba uahevzxf ehhj XKW8 tfx REF6 zfi bnwaxpbfz. Sx kpjs ab ajzvzkybg cyb rlqhvp cpa xooahfgcg, bryw ncpxu caw qww dino pi jqboxht ncvae mb kgpdefiwq tb d fypihvu'w yclsmop bx lhjxlk gq vxsaenkp dy eam jq vym DFA1/FAI7 mdfzlsye.
Pkrcprorr ptzrcq nf Reyjz gq 7 Qnpqwbkb 3251. QPC: 34.7701/gixbe-9644-77-170120.
Pgj xexwke pzg uxst rrcojlzvhxy udtftu vgtwy: lgfx://k.xgfc.igb/KHPGiw553474.
