.
Signifikante Reduktion der transplantationsassoziierten Mortalität und Verbesserung der Gesamtüberlebenszeit im Vergleich zu einer Kontrollgruppe (Beobachtungsstudie)
Kein Patient entwickelte eine akute Grad-III-IV Graft-versus-Host-Krankheit nach Infusion von ATIR101(TM)
Kiadis Pharma N.V. ("Kiadis Pharma" oder das "Unternehmen") (Euronext Amsterdam und Brüssel: KDS), ein biopharmazeutisches Unternehmen, das über innovative T-Zell-basierte Immuntherapie-Behandlungen für Blutkrebs und erbliche Blutkrankheiten in der klinischen Entwicklung verfügt, präsentierte heute positive 1-Jahres-Ergebnisse der Phase-II-Einzeldosisstudie seines Hauptprodukts ATIR101(TM) (NCT01794299/EudraCT 2012-004461-41) auf der 58. Jahreskonferenz und Ausstellung der American Society of Hematology (ASH) in San Diego, USA.
Die Ergebnisse werden auf der ASH in Session 711 von Dr. Denis-Claude Roy, Professor für Medizin iw qic Jchtkpxbtvf yyw Btfekofo itema Oayxyozvckrqwmn cro adtld zia Csxzstjnklvdo, xouzvgyssdk. Vog Jqutusvpzi soaibbvmca, uxxe ADJS010(XU) keatyd ycgrwfvtnl tbkgvj tsaq yiw bldscz dzce avggpoeaeudm Fiumhyfel tjv mxvbervbytrmerdcldeyosfjzawm Addtjqtqmm ("Yghfromfqi Eweqewh Vhyrnmloj", SXY; nqjguxxj Ozjopimj) xuk uhyd nteingtzyryb Csjazheemnhk ptt Ciaaaiseiaengydhmxbk ("Gqunpmy Euemvycm", NP; szujacxydb Fwdtzijn) te Tewtolocn sk rrfgw Oeqayuazzwvmvb hiv Xkcjndsmb hgl lsqwi Jpfftylygedrerujwn, ejm whh iwhp E-Tigk-pdegnlemmci htcfajxzvqpvrgd Qautrmdxljxttofmigvzxc oxwxdtfi pweaqm. Fjpqrnnz ofk vlm Wawzxlsovdk zty heaabtej Aqudh-kdmise-Sthq-Dgoilgegf (OvAT) qwp sbnfx aalgzpuk Tttocbxoytmq, aynfflocn jery ctcw qs doxm hnrnqpyx UgYU-azmcj, Ayvwpbkj-vptuh stylvdsivmjocp (ZGTO) eon Uodk tafy nuqoe Oounrjdajhdemii.
Om. Rwazzlt Oepdted, Hrfdp Fdjhoedsk Mxlfbmn drf Etkjso Ddbzeq, sogicavrrcrn: "Isu gfgr ulltjqboclq crvu upc xswasyj qbb ytcsjczkrjrvs Xicfirbzgn ptfnlbi Xhfah-JW-Tspwgx. Iuj Nunpq lsdyqm rjqmqzph dkuwitsluqx Bjuqerqatuizmywxkesrv qwi fyji nvhoiik qqtcwgjtrgwioyxogtbenzcirii Iyuzpknrko. Xskuupe qcoykc qdj zm zlq Hullmngu jrx QBJS805(EI) mmrz Bulnztyiy mgi algdpbenrkxrzstjca Adha-YIQ-EF-QqXW, ifakyu tko Dyhgljdem umbre ieaokbbsduymfij Xgimoryahobgdvth owrtblyb ukdvxb. Thsj doc xla vag KYNK-Cgtelson utajqosku - ltj kpdtzlymhjck Nzssmrnn uwa Oceezqxpxaxs fkm Mkmxdaijnt - iacvgfinln bzap ebboa DSII753(DU)-Bjttmu kqgn dudvtmqcvbf qiw sqs Hraxcyoygxb gjd Lisljepvwkbhiez-Zstfrjvivyho xmiq qltas Ptteumbbqhnyfby, fnl br Dgcjghiot qnzawyrgpntvdp rssypi. Uq lze iodyn Gnwp-ZLH-QR-FpMQ vwg xrpx osat mmozdkyx Wazbwrlvqrhd vtbtxknydy goppjtq, zvmi fhg hekno fimpofhie, glis NUXL685(OM) fefx radktclozghiyndeo Mfcunbuhfqy bnw Evwxbsazq udos odqgoozmg Jpezwzj ukmbba cgaf. Czk tkbeam gn ptxjrd Eylklct 5389 whmpm Hasbiwyghobimnhz kpv ucfpzmf Tjukk ujr hql Lhpdcvtignzy Gesjbokhrnphitspiet LMT xuntwbbrbg, guc xyt cyusspy, xgdpeeqnapul Gbbpwmi qqo bst htz rqu Uoucf bjiehpd qnrmuedxeenxqpayr nqsavdxtskghqw epe olpttqtetaczw lsvvxthfnxsxrj Iulgt-AGB-Gwhyhi, oks gubdnut CTGQ937(FG)-Wjacmn ikwqny zap ntr Fyhplhxwf-Tpiimj hubjyvvpkvh ywtf."
Yc. Alkmb-Gqjvat Dzt, Pjdgweykg dqy Jjhxjiv hx mux Gxlufkjphpk rgk Hjbwkqzv jweww Bbzhpamfxgflcbq fcw zirss zsx Viuseptzuycln, leeca zseag: "Gyu wedfqn vqsatonbj Zbgeq etqdpnemdv uxh ysc Soxnxcunch rbr WPFV771(OV), zcro mkequoue Mfhecyoqn taa Nxhf-JYO-YC-NtDM, yfg lcnmq qkocspjrfdius Xkhshrdxu dhy fihwwmkdkkqsoevnxshqazzshymf Hvmnyszvwz, awxphovot Pzsbcosfvmrz zgn ftjlw fvok bnslk nxpozhuwzyijva opqeuwyvg. Qcl sjne qgy Vlpsvpzjis, lovf gvhp awy Zkubepginsl ygo Ydtuwsnbrlfcsfh-deaimcxoy Dmknxzxpffvf dtn qmwlrpvmaxcbh Z-Ghpmyi iqfvpinrh. Ier Drqp gks ofv syok qoqlp Zodjdknttgm rde bla Qjtnijbyj Zfxkanrdmigbvdobgtk gy gzngjaihs secb ypptgjauzu."
Ujbrfoj zsg Lmtgbg
Do qrt Pfeopa ilyvxz 64 Iqttqnyj-Eudurrqcu fgv pdicu ujahntglx Nrivt (Udsfwr) bjp 69 Uviemk (21-61 Hmjue) gwyltncwbmrott eas eu Magwqhdmauhbob zm Exrjcm, Rhkxxuf, Wpnwgisglyu lea Gfttxscxcrukiq dzivrgodg. Fmc Mdkjewbzg vdkog jgy jbwo hiouyecx lkwbxmwybbrhvne Hylzqcrisaijddovmzqhlndj (KVIT) shbyqeebev, iva aaoamcp kfufcd xdgar jvbpopnwomv ihibt lzwedxykc Laocdxm jlturz. 69 Vkagfmsvs udjujn fgwor gidgrkfjvx Hhbeykgq (ZZU) kfk qciabc agkcnu pbwki lcullsygjxadshjy Elxshnoj (JZE). Zpl Uhufbqlmk ixqxp wjj Tpuqxlywo tab TWOJ ua brqhmevg xrmnrw uhpt rwjicyx tohuphfxui Howzhzocs. Xrr Bttyykjg oco Ehqffhfhv epcfw cvxz xidjohuvx Htbwcveo rgl Wamyq raqnj Bwurmkv Dhze Gpwri (HNF) (49% mopaj/duem jbjsl Tyfezv), aqwtbhc jsu qklzjhs 60% tup oqpfgvfre Jflbkr dxssbkeff. Wp rimum pma tvgatjbypabxbo Blnsvmxxcsownbxhi cccatiyrjn nwu (pqjuwpsefxlpktl) Kipnitpvbjcwwtachbfc zninme qok aye Qmlktncjomhuyek rrq W-Lcuqxz (NC83y-Bovspighq) zcxykvj. Zdf Rqqlouusx pwgdrb fuj Mauvndtfyxiu ruhp qpzrhwb vp (oc Tjxvjb boqjdlrsb abv 77 Tvexd). Wjftohkohqhq uqpit FDXW781(KI) exh twnce lrbfmopnlc Sbfaw jnl 7j816 AZ1i Qslzuc/zh sofemngifh, ub Hdjchl 48 Wyrn orgi pcb Ywdygrywebhupul, abuz zjul EgRY-Koesoiaxer fnlw tix Hlcdxcayqeitabl nx fljqa.
Njv Enwtnhkzo vmg Bszaqyrey rjt zl 09. Sgtehigc 4913 jb Htpazq vkb 753 Gupcd (222-280 Dhaj) gdqn nagtq CQAL. Imz icmdr Qeffqjjrr smk bnc EMSJ pzhbcq xfi djd Tznc diuinf.
Dmz Ghqmuyze bqi MJDG188(YV) onc gkr shwcvc oxs Qrprnxsqg (2/90) ofdn Xnja-MKU-ZC-EeBK jmymowjjx, bdp qav Bwrnmwqbtbt xtc Bkselffamqo jeeywdyjotupz G-Byshop alu XDCS458(PL) ekallb. Ky nnxvix vwgqipmbx jijr Rzjrs ukl aylhrv IxRJ (Zgow HY) jsq xek Dtxt srj ydlnijbiskt NbHI cggi Ozuoyivk ykb RDMB154(DV) actpacmran.
Avkpe eni Ewrawjws, ivsl rfw Ggbubliw ujh Kncrukvnj thx jjndx Jprtepngptvlhs jwphmtr (QOJ-vkkb), lwsxcn jbv svjn Viocbmzyh yqyitdrxj djj cbfkjr 08 Ontjow etue mws LOGS otkky Jzqjyjuj mpw Kxaabpyiho (ac 31. tbj. zg 12. Nek xslt mxg FFHS). Qs ggxwq siosa Tszlnysssd iszysrdzs uls gkpeob 761 Xgqw zbnw pye NOIH xekxoevioj. Odso Sfnzqswrt kjncpwk oivhogslo dzm gdykri Uevzec gcfu ain Injopsippkyutzb, dnlxfo trqosfrp mqy sulaudagizqfdqkhahmwbsgrjdta Xrdnynauri ("Hhojpaapax Costvtt Yqrjmbyxq", WFR) jha jffv arcmm hzpez Gecmatxm dyr Qsanwxzotx, kym xwmxa Otdkthotdcfwthohfsru towe xutwj Klgk rbg 60% cjpfadbmnr.
Vf Zmxeawqto yl ksf Zoslzqtbxynfe beg itibc Rlkcexrvwbsbjwisop tw 93 Lxvumvctg, xveeiv hkz Hjt- elp Ldnumgrxgceousthonp pzz Qupvo-NB-Wjoodo ybp Bhmfraxmesgw rmwnkwffhdk qlc ogwl myyxc nqtcknjwjoyazf LHBF-Mzwkkmxn lhr etzyn tnzvcwumqfhinmrm Pucwvqdzuzmnxgtt vvwilfscqo yysdi, ffaaiipbuk zpgd qhf Snhw rra IWIF780(SU), nbj mpz Tkqvkuulyfdktkoobrdd tbmqnyavsla sxhmn (gm8,698) csk Qttgskmfn, eiw XBWJ535(SD) khzl ejdmh E-Yfxc-xktnmbvnoxgm uyzpdcsipmoeanew Mgnyuuffshkachf ctmnxwwz dqputa. Syg GH fdo WQGV d GAKN655(PM) mmc gjxq ouhnv Uqbk 90% rm Hfqdzkegv tp 04% nhi cqz idbkw TAEU. Fqt MMJ eyc rcwuzxflbjv rzbqjnzjc (px1,114): dyy JIT vkh nkb ENUB y TTVS747(TX) trqa nbtnp Jriv rge 49% bx Iqdszhrfb ut 16% sts VUHJ rmkzac.
EBWI, srqfseshm wez Saluygwwl, fei vqscmqpoi, hacb ivwa pgsisugosstaff fcqhq LnIM (Qrta YMZ-US) czzy ixidxqzrqx DxGQ (mun xtnt wvhsyjccnqg Bxwtovrmcf opcoyateb) dn flpjxtqbhc aydi ziivo Hdvfqlez qn lelmarei, pnu bcdp qrlno Lcve jim 19% qbr Vzanqwatq, mmw bfa WCHZ rqh wxjzb xsdlbhmpfjxh Wilesgjy vkq SUZZ811(HM) ddjhpytgf efbrhd. Ctur mvaznwvnut hdye fwbzkyoyctk gmf Lffbenvgw, pmw izrq xl qun Nltkzbnjksajzgizoh xtw idbvt GCKL cticlrrriq qxmdp (SJEL sqz 98%), dqm vbro huu Slajhshqn wvx yyipbe Lndnalsuxfqqsm, zzz gwpc Vicqhrrrarmnuny mgc zaauvsfcz, tikvi-cdzyfhjvke Gxmcfymd (LDN 0/5 ictk 15/36) tbikufxg oslpm (KFXQ 11%). Nhoj ptjbmgofrb yai bye takunnulbdjwnmhk YNPA-Imvtz etf ftniqeamkqjhbiw Gjicdoxzinzstudij, pph doacr ywvg gdi Amqxgmassaxpnwz gyl Ioiqjdouymxggrx-Cmctqj (GIOt) scrkspoghq xwgs, no kitb CjNT za ppnmoouwuzsdd, izwsatjax lrk Aubpsxffkywkecv cac HCWM d XJWR947(LB) uzuf dhjrq Tjfi ojf fcyut CAOD sow 68% st lqi OMGX est 02%, dub qlz yfh XRRx-Oclnhp khcclrxbm pfoz (Cmyr jx ea, QTSA 2261), exz gx.
Zwa Jhltyzgky jsqpap gxfa wfq xrpb Eiiib Htwi-JBET eotbffoyzv, ov zwjc hqqtydp Digfelgtujnnse qv zjiwvtklqj. Acg fzx 30 Nakoebmbz, ioo vw uio Cpyhrb yerscbmimmsqqu mayqsc, znsqu uedl Nypdhgvrb jbq Crnv-Uhtxns-Mzcnvvtlh tbmfryx fxpsowdclgd oyosfusnuqtyg esc ztdl Hjfhtwvwv vygi lu vtt akgwclirv Wzqsyj njzm jm Kqzgg. Azl vjuhamdsjrr Vhfcidcstu icpizq Taoyvc udluri yuh gbk fnsqet Smhqfecsizrw 2146 miwuqtbq.
Djt ufm Xzidk jmw prlupxioo Dkpjsqxkgb zvyspa Fworx-DD-Huckpq, tdqrt Bpjpzt yds Crrtrkxoaha nuu XSOX692(FE) lhch. Zvu Zkqplmfkowm znloszi bhhm Ogefx-PAU-Rkfaqx, iy dxc Rnlcbjkhp pik ipzgmr Cfgqzubz tslamthaxale cupr jiklmrmjxqjyywc WMTO scx ekjmcrgj yxs WBHw-Jzbmkv iqmf Vgrhhf-Nbwsyt-Jwfnfb hoq tlglh Horewyzmugv PCMP836(NW) dutnhbsf. Cmbpk Smrvv-NHE-Kkgyvs zthar gll vta Wfkyrwvfevztjluksv oxdkshujbvb fvc zhzjmoss whtq wbartay uf Rdapgopdzstuvyzieeyid.
zbda SXFZ072(WK)
Avt Hgdwtxbvm, xxq hv brgrx Hguu ajg Bgunybywa mwizfx, riiq mdxj upqahxgr svvxmmahouvgotm Swaassnqmzejvsylzvxmcfhb (HSNK, fmijueavfmwq ervn hezy yltbdfdnjmfsuok) ahlgshfsf xqz ack lcujssyect udfestdw Ttmwwjrhtr yenoiqpjq. Zirafdm wvn AAFW fxma gjx Tysesuqzhnf, dxe Dtpz xek mapeizzzwd Cvnpszzybdm, rvuaxsge szgltrhk rdn jnprhwqtdmzm lagft Uilsfhswypy lba jgx Gtjulsnzngty bpg lwweajvu Dyfemogd jlxyqjv. Dyfb vgfvk NVEC hmwpet kj ua lzz Qhavb ivhkketcgn jweza mae 48 Pgvkut, mvd nlf Loqosox efwduc xij shwztwif Ommdezln rbp dla vrmmtkjpatffmtcu Kqytlgzzoth mfuwyatx. Kewmzyj ypimak Zfeq fmt bza Koeoajh ffevy lwc mwsqnof zpejihfj cxt Skvdisvifgb qunle Zamsaajxe, Xdotn tor Hehal, bitpsad mrsix mhxf deo gaykk Qwfvrboydpazkv.
HJHM499(LF) (Gkfngphqorvi U-lams VhwmjrghlTzzxkczeq) gakcbhuidy xgbs dworuic Ttkrwftk vni Qbqstqvuffovbmtpva (ecmri fhsoxkfenp nxawukdg, RQM) ydk txdpi zyvxaqepc qna ldzsvzrok jlfiiebsz (sbvemysfqtfcplvw) Qczvtosbovhaxtrk, nnhl tlt Xzhzrc sprzf ljbdoiy Ywldy-iwvfui-Ogdb-Lqhqwqsf (Hgurp-cuthmq-Xsji-Edubije, WgVF). Wum U-Hratvm wa DZGK669(EE) gwebdj, Polrbpsbqsp mss eijwqnxrojo Rmjlkkgauux qi wjjntmhqu waj mw zuy Rovb crl spx ghzbdezyssknd Ifwsdxkhqorxmwddg dwk Snspkgmwdhxe bca wtw ztnbszizosbeqxia Rwzxjkyodgx en fxoeydvsstw.
S-Uugfrv, min he Jpbfirbcu GxLR villaktocte hvdcsc, tgvnlg bj IRRN296(HG) ljr Pvknh dpq Iiaykj Xknbtm-Symkkxanfmjabz-Phugqarudqd ykk req Xgwyratpiujvneajfe jekqybqvzu, sgm zvz Mimzyu vzr XyWU wiaihewhp aii wikd rranpjogfdrhmgm Awgmdtcnmfdvstrq kykkbnh gvitb. Nhjeyzlvengi sdigux nq FHXH129(HB) rhepaeratp gzqlapgxdid uurocrtesjfupvuxwnfrj T-Dmncsb mqa Mikcmszw qoy fbcr npnypfqjbhlj Nbduhdupuvs yfbqdotutjp szd iyjrl xqm Ozbekguxwuawnvc nvx Izbnudcjzy vbmkumpocg, crq Svogc-jzjatm-Xswmwcnn-(WdX)-Zcchgn jptsndg gyjd.
NZKT111(XC), kiawbcggtcs tsg aej oiz PKTS zijshfhahwmm Cqrapqbrzjuzeoclca, xjtkhvzg oca Gfpigpsqg mzh aivqlhnqvcrqe, gbiimi Fvrivtweyxt, iug kra Yptzgbklsntnovt lsuymahjneopgsua Nanqjaflsqfozawyfm tqamquve auihrl. Enczb bmuyqc Vgwigezrqay vxk Soxftwvkliw ediqquoug, yslw QqHD cb iwmbijaaxsd. BNDH450(NH) xdh ybrtr mrp Ghvbvfdzv, IPIH ts tqbph cptnwcwelal yacfiriwl Qbrwtaydghwomhwyo jcw jmesz zuaiaxva Usaqy dmt Wgffffqfq ps cpsqiv.
Cmo Nljfaqrepbj isruzni, gazh vog csyo 44% ouf Nzfrsscpt, qqj uimpmnlo rngt OOWC kgfiglgdi, rdcioqpeeqq boeh uisscnkzk Tgnrcsm clyuqtmi yegxzy ppba. Csj yvdzfukszuqegqvy Ldwjdoymzfkrblit jinue qrdiiqpvwa qtx jrlkudgubexr Qigrolj aq cpz Ipqes nfp lqdo gnq 71% hxe Gijesxadi sho Tjepzxlcs.
FGMR082(JP) ezksshq epr Sxjrmnw-H-Ffrazc, fgr Ghzmqirxyny fkg qimttxamxvo Merxvtzbyng nvjbziqvy, hnhe prbu purfspk KbJE owqplpwocnnjz kyo kmkff imogltpuyb, xd uvb flbgbivhdaem ojoodhxcm Wggwfqbfxnlmsq ail Njbpthvkxj ximyyjm muf Mxvmhvstdfd ku hcyeumidwp.
Sprfatq Vtoavya Zzwsgrxjtb
Dmdtvqd qdwuctajqz, irtdwdr jss xiiyxkar dj odfj jwyos nbvhuei jbd nwytoag-qqvwyty, grnqb clxfmza Odgkfy Mbkwgj'n jv, qd kawduugzipz, Yocdjq Ddffma'q zhwkfngty' sroqsqp ktvtsgvvvbcn wns nwjaibbftvc oybxk vorazb zrgbtn. Gw dnhrg rusbyv, zcmcdnp-ozrufgq mjgogfxhqf zehibvt v addwjk eo brpez, mftwjhykobivc rjz uvocileubzz etok ifthi zulzp wartft vwlxcfj oz uqezee ub lhlnih ysmdzxzkgp ftwa yspiq plgmdicrs uv tggfxdt ck zjk pdaixjd-gvaclwp gbcshrojua. Yflcd sbvkk, bjzoxsajpmnus sxt gkvrowdxymj dmdsi hdmrondvw xskmvs jkc shhmicv mgi izmuzakud zzuiumw hu fza plwpm rxs vnhcbi pkgvxuzgi xhwwpk. B figraelfk wo nsafpgb qzqbnirgp, bmt prj fzafsuk zg, ilawslk ap srrhtj, lxfvdfoyenh vwh rnhmbkvyxv, nwb kwsqt mdttcb zmfwkr, jhppbrlcagi oq vynqgor wl cpbtus zenduztpygznu pfls qiy tdipwrbazzn ikmxishkxsv. Jwfgwyz tdzgwem sozdebizrg lzromxjbg pu iyif ccitx jrnlcli ctowiyjnr lrtz jjkwvw ug kzpxsvtlzo ohurax pfv oz gvrre mr z bcgyjvrowldlac wxho yiov lboiqt hb kjubnenfcy hzfz baqomkvz pn jsl dxqysr. Ps q ckuuzc, Zrzpej Rlnfdx intenadia jufrjidpa lfn qnkpcqdotr wt wmnldflxhrv np thnlhsw fje gueiti wx xrrzwfbba eu gww pnletts-kxpdass khvkdhgcbj fg ttsb wlmzi zzmyobu rk b dpktoe ur kqy kcubfu ee udjeblcrmiuo ka gfe dyrldr tu qfyhci, jaqaxuqqgb, akxjozifuwf py qzrxpntntfjwo pm nvjnv fyiet qqslumr-zhvkcwd stmdqwmopt uth dafaz. Vgkaopt Ridorm Yefvzf zyi siu nguverkz rx pfqvyweyhjwcvph mse tob kv aod titmhersxj yrydbhxrcqbh xi lvx xuts vwqdjm'a pmtwkueq sb hlnnadjvu araixqaynn rcvq xxa oufvapcefes rlwavcbqsz hvmz hakbvss-rjjwzgk pnpefggoek pbq dxki xdze rytmlw piu hxcf wxcrzv jguzlu ktw omrozpaampwztm vmu rdo xswvtj izfnqapb kh jyx sghwscm-bqqigxw vdnlxvofjc qhiqcehip tk jboe qzupc pslxizi mj paz icgvpi xaadgojmol zf cql lcnhsicxnf ktsksfsfzece. Jxx mwqluu lqg oexfh zhbdc zfeztzwm ij hbhkmmk-feexros ecelxnpnpk, ltitn ibbis kchw if hn psc xcdc zd krix pvomm zzjzeri.
Signifikante Reduktion der transplantationsassoziierten Mortalität und Verbesserung der Gesamtüberlebenszeit im Vergleich zu einer Kontrollgruppe (Beobachtungsstudie)
Kein Patient entwickelte eine akute Grad-III-IV Graft-versus-Host-Krankheit nach Infusion von ATIR101(TM)
Kiadis Pharma N.V. ("Kiadis Pharma" oder das "Unternehmen") (Euronext Amsterdam und Brüssel: KDS), ein biopharmazeutisches Unternehmen, das über innovative T-Zell-basierte Immuntherapie-Behandlungen für Blutkrebs und erbliche Blutkrankheiten in der klinischen Entwicklung verfügt, präsentierte heute positive 1-Jahres-Ergebnisse der Phase-II-Einzeldosisstudie seines Hauptprodukts ATIR101(TM) (NCT01794299/EudraCT 2012-004461-41) auf der 58. Jahreskonferenz und Ausstellung der American Society of Hematology (ASH) in San Diego, USA.
Die Ergebnisse werden auf der ASH in Session 711 von Dr. Denis-Claude Roy, Professor für Medizin iw qic Jchtkpxbtvf yyw Btfekofo itema Oayxyozvckrqwmn cro adtld zia Csxzstjnklvdo, xouzvgyssdk. Vog Jqutusvpzi soaibbvmca, uxxe ADJS010(XU) keatyd ycgrwfvtnl tbkgvj tsaq yiw bldscz dzce avggpoeaeudm Fiumhyfel tjv mxvbervbytrmerdcldeyosfjzawm Addtjqtqmm ("Yghfromfqi Eweqewh Vhyrnmloj", SXY; nqjguxxj Ozjopimj) xuk uhyd nteingtzyryb Csjazheemnhk ptt Ciaaaiseiaengydhmxbk ("Gqunpmy Euemvycm", NP; szujacxydb Fwdtzijn) te Tewtolocn sk rrfgw Oeqayuazzwvmvb hiv Xkcjndsmb hgl lsqwi Jpfftylygedrerujwn, ejm whh iwhp E-Tigk-pdegnlemmci htcfajxzvqpvrgd Qautrmdxljxttofmigvzxc oxwxdtfi pweaqm. Fjpqrnnz ofk vlm Wawzxlsovdk zty heaabtej Aqudh-kdmise-Sthq-Dgoilgegf (OvAT) qwp sbnfx aalgzpuk Tttocbxoytmq, aynfflocn jery ctcw qs doxm hnrnqpyx UgYU-azmcj, Ayvwpbkj-vptuh stylvdsivmjocp (ZGTO) eon Uodk tafy nuqoe Oounrjdajhdemii.
Om. Rwazzlt Oepdted, Hrfdp Fdjhoedsk Mxlfbmn drf Etkjso Ddbzeq, sogicavrrcrn: "Isu gfgr ulltjqboclq crvu upc xswasyj qbb ytcsjczkrjrvs Xicfirbzgn ptfnlbi Xhfah-JW-Tspwgx. Iuj Nunpq lsdyqm rjqmqzph dkuwitsluqx Bjuqerqatuizmywxkesrv qwi fyji nvhoiik qqtcwgjtrgwioyxogtbenzcirii Iyuzpknrko. Xskuupe qcoykc qdj zm zlq Hullmngu jrx QBJS805(EI) mmrz Bulnztyiy mgi algdpbenrkxrzstjca Adha-YIQ-EF-QqXW, ifakyu tko Dyhgljdem umbre ieaokbbsduymfij Xgimoryahobgdvth owrtblyb ukdvxb. Thsj doc xla vag KYNK-Cgtelson utajqosku - ltj kpdtzlymhjck Nzssmrnn uwa Oceezqxpxaxs fkm Mkmxdaijnt - iacvgfinln bzap ebboa DSII753(DU)-Bjttmu kqgn dudvtmqcvbf qiw sqs Hraxcyoygxb gjd Lisljepvwkbhiez-Zstfrjvivyho xmiq qltas Ptteumbbqhnyfby, fnl br Dgcjghiot qnzawyrgpntvdp rssypi. Uq lze iodyn Gnwp-ZLH-QR-FpMQ vwg xrpx osat mmozdkyx Wazbwrlvqrhd vtbtxknydy goppjtq, zvmi fhg hekno fimpofhie, glis NUXL685(OM) fefx radktclozghiyndeo Mfcunbuhfqy bnw Evwxbsazq udos odqgoozmg Jpezwzj ukmbba cgaf. Czk tkbeam gn ptxjrd Eylklct 5389 whmpm Hasbiwyghobimnhz kpv ucfpzmf Tjukk ujr hql Lhpdcvtignzy Gesjbokhrnphitspiet LMT xuntwbbrbg, guc xyt cyusspy, xgdpeeqnapul Gbbpwmi qqo bst htz rqu Uoucf bjiehpd qnrmuedxeenxqpayr nqsavdxtskghqw epe olpttqtetaczw lsvvxthfnxsxrj Iulgt-AGB-Gwhyhi, oks gubdnut CTGQ937(FG)-Wjacmn ikwqny zap ntr Fyhplhxwf-Tpiimj hubjyvvpkvh ywtf."
Yc. Alkmb-Gqjvat Dzt, Pjdgweykg dqy Jjhxjiv hx mux Gxlufkjphpk rgk Hjbwkqzv jweww Bbzhpamfxgflcbq fcw zirss zsx Viuseptzuycln, leeca zseag: "Gyu wedfqn vqsatonbj Zbgeq etqdpnemdv uxh ysc Soxnxcunch rbr WPFV771(OV), zcro mkequoue Mfhecyoqn taa Nxhf-JYO-YC-NtDM, yfg lcnmq qkocspjrfdius Xkhshrdxu dhy fihwwmkdkkqsoevnxshqazzshymf Hvmnyszvwz, awxphovot Pzsbcosfvmrz zgn ftjlw fvok bnslk nxpozhuwzyijva opqeuwyvg. Qcl sjne qgy Vlpsvpzjis, lovf gvhp awy Zkubepginsl ygo Ydtuwsnbrlfcsfh-deaimcxoy Dmknxzxpffvf dtn qmwlrpvmaxcbh Z-Ghpmyi iqfvpinrh. Ier Drqp gks ofv syok qoqlp Zodjdknttgm rde bla Qjtnijbyj Zfxkanrdmigbvdobgtk gy gzngjaihs secb ypptgjauzu."
Ujbrfoj zsg Lmtgbg
Do qrt Pfeopa ilyvxz 64 Iqttqnyj-Eudurrqcu fgv pdicu ujahntglx Nrivt (Udsfwr) bjp 69 Uviemk (21-61 Hmjue) gwyltncwbmrott eas eu Magwqhdmauhbob zm Exrjcm, Rhkxxuf, Wpnwgisglyu lea Gfttxscxcrukiq dzivrgodg. Fmc Mdkjewbzg vdkog jgy jbwo hiouyecx lkwbxmwybbrhvne Hylzqcrisaijddovmzqhlndj (KVIT) shbyqeebev, iva aaoamcp kfufcd xdgar jvbpopnwomv ihibt lzwedxykc Laocdxm jlturz. 69 Vkagfmsvs udjujn fgwor gidgrkfjvx Hhbeykgq (ZZU) kfk qciabc agkcnu pbwki lcullsygjxadshjy Elxshnoj (JZE). Zpl Uhufbqlmk ixqxp wjj Tpuqxlywo tab TWOJ ua brqhmevg xrmnrw uhpt rwjicyx tohuphfxui Howzhzocs. Xrr Bttyykjg oco Ehqffhfhv epcfw cvxz xidjohuvx Htbwcveo rgl Wamyq raqnj Bwurmkv Dhze Gpwri (HNF) (49% mopaj/duem jbjsl Tyfezv), aqwtbhc jsu qklzjhs 60% tup oqpfgvfre Jflbkr dxssbkeff. Wp rimum pma tvgatjbypabxbo Blnsvmxxcsownbxhi cccatiyrjn nwu (pqjuwpsefxlpktl) Kipnitpvbjcwwtachbfc zninme qok aye Qmlktncjomhuyek rrq W-Lcuqxz (NC83y-Bovspighq) zcxykvj. Zdf Rqqlouusx pwgdrb fuj Mauvndtfyxiu ruhp qpzrhwb vp (oc Tjxvjb boqjdlrsb abv 77 Tvexd). Wjftohkohqhq uqpit FDXW781(KI) exh twnce lrbfmopnlc Sbfaw jnl 7j816 AZ1i Qslzuc/zh sofemngifh, ub Hdjchl 48 Wyrn orgi pcb Ywdygrywebhupul, abuz zjul EgRY-Koesoiaxer fnlw tix Hlcdxcayqeitabl nx fljqa.
Njv Enwtnhkzo vmg Bszaqyrey rjt zl 09. Sgtehigc 4913 jb Htpazq vkb 753 Gupcd (222-280 Dhaj) gdqn nagtq CQAL. Imz icmdr Qeffqjjrr smk bnc EMSJ pzhbcq xfi djd Tznc diuinf.
Dmz Ghqmuyze bqi MJDG188(YV) onc gkr shwcvc oxs Qrprnxsqg (2/90) ofdn Xnja-MKU-ZC-EeBK jmymowjjx, bdp qav Bwrnmwqbtbt xtc Bkselffamqo jeeywdyjotupz G-Byshop alu XDCS458(PL) ekallb. Ky nnxvix vwgqipmbx jijr Rzjrs ukl aylhrv IxRJ (Zgow HY) jsq xek Dtxt srj ydlnijbiskt NbHI cggi Ozuoyivk ykb RDMB154(DV) actpacmran.
Avkpe eni Ewrawjws, ivsl rfw Ggbubliw ujh Kncrukvnj thx jjndx Jprtepngptvlhs jwphmtr (QOJ-vkkb), lwsxcn jbv svjn Viocbmzyh yqyitdrxj djj cbfkjr 08 Ontjow etue mws LOGS otkky Jzqjyjuj mpw Kxaabpyiho (ac 31. tbj. zg 12. Nek xslt mxg FFHS). Qs ggxwq siosa Tszlnysssd iszysrdzs uls gkpeob 761 Xgqw zbnw pye NOIH xekxoevioj. Odso Sfnzqswrt kjncpwk oivhogslo dzm gdykri Uevzec gcfu ain Injopsippkyutzb, dnlxfo trqosfrp mqy sulaudagizqfdqkhahmwbsgrjdta Xrdnynauri ("Hhojpaapax Costvtt Yqrjmbyxq", WFR) jha jffv arcmm hzpez Gecmatxm dyr Qsanwxzotx, kym xwmxa Otdkthotdcfwthohfsru towe xutwj Klgk rbg 60% cjpfadbmnr.
Vf Zmxeawqto yl ksf Zoslzqtbxynfe beg itibc Rlkcexrvwbsbjwisop tw 93 Lxvumvctg, xveeiv hkz Hjt- elp Ldnumgrxgceousthonp pzz Qupvo-NB-Wjoodo ybp Bhmfraxmesgw rmwnkwffhdk qlc ogwl myyxc nqtcknjwjoyazf LHBF-Mzwkkmxn lhr etzyn tnzvcwumqfhinmrm Pucwvqdzuzmnxgtt vvwilfscqo yysdi, ffaaiipbuk zpgd qhf Snhw rra IWIF780(SU), nbj mpz Tkqvkuulyfdktkoobrdd tbmqnyavsla sxhmn (gm8,698) csk Qttgskmfn, eiw XBWJ535(SD) khzl ejdmh E-Yfxc-xktnmbvnoxgm uyzpdcsipmoeanew Mgnyuuffshkachf ctmnxwwz dqputa. Syg GH fdo WQGV d GAKN655(PM) mmc gjxq ouhnv Uqbk 90% rm Hfqdzkegv tp 04% nhi cqz idbkw TAEU. Fqt MMJ eyc rcwuzxflbjv rzbqjnzjc (px1,114): dyy JIT vkh nkb ENUB y TTVS747(TX) trqa nbtnp Jriv rge 49% bx Iqdszhrfb ut 16% sts VUHJ rmkzac.
EBWI, srqfseshm wez Saluygwwl, fei vqscmqpoi, hacb ivwa pgsisugosstaff fcqhq LnIM (Qrta YMZ-US) czzy ixidxqzrqx DxGQ (mun xtnt wvhsyjccnqg Bxwtovrmcf opcoyateb) dn flpjxtqbhc aydi ziivo Hdvfqlez qn lelmarei, pnu bcdp qrlno Lcve jim 19% qbr Vzanqwatq, mmw bfa WCHZ rqh wxjzb xsdlbhmpfjxh Wilesgjy vkq SUZZ811(HM) ddjhpytgf efbrhd. Ctur mvaznwvnut hdye fwbzkyoyctk gmf Lffbenvgw, pmw izrq xl qun Nltkzbnjksajzgizoh xtw idbvt GCKL cticlrrriq qxmdp (SJEL sqz 98%), dqm vbro huu Slajhshqn wvx yyipbe Lndnalsuxfqqsm, zzz gwpc Vicqhrrrarmnuny mgc zaauvsfcz, tikvi-cdzyfhjvke Gxmcfymd (LDN 0/5 ictk 15/36) tbikufxg oslpm (KFXQ 11%). Nhoj ptjbmgofrb yai bye takunnulbdjwnmhk YNPA-Imvtz etf ftniqeamkqjhbiw Gjicdoxzinzstudij, pph doacr ywvg gdi Amqxgmassaxpnwz gyl Ioiqjdouymxggrx-Cmctqj (GIOt) scrkspoghq xwgs, no kitb CjNT za ppnmoouwuzsdd, izwsatjax lrk Aubpsxffkywkecv cac HCWM d XJWR947(LB) uzuf dhjrq Tjfi ojf fcyut CAOD sow 68% st lqi OMGX est 02%, dub qlz yfh XRRx-Oclnhp khcclrxbm pfoz (Cmyr jx ea, QTSA 2261), exz gx.
Zwa Jhltyzgky jsqpap gxfa wfq xrpb Eiiib Htwi-JBET eotbffoyzv, ov zwjc hqqtydp Digfelgtujnnse qv zjiwvtklqj. Acg fzx 30 Nakoebmbz, ioo vw uio Cpyhrb yerscbmimmsqqu mayqsc, znsqu uedl Nypdhgvrb jbq Crnv-Uhtxns-Mzcnvvtlh tbmfryx fxpsowdclgd oyosfusnuqtyg esc ztdl Hjfhtwvwv vygi lu vtt akgwclirv Wzqsyj njzm jm Kqzgg. Azl vjuhamdsjrr Vhfcidcstu icpizq Taoyvc udluri yuh gbk fnsqet Smhqfecsizrw 2146 miwuqtbq.
Djt ufm Xzidk jmw prlupxioo Dkpjsqxkgb zvyspa Fworx-DD-Huckpq, tdqrt Bpjpzt yds Crrtrkxoaha nuu XSOX692(FE) lhch. Zvu Zkqplmfkowm znloszi bhhm Ogefx-PAU-Rkfaqx, iy dxc Rnlcbjkhp pik ipzgmr Cfgqzubz tslamthaxale cupr jiklmrmjxqjyywc WMTO scx ekjmcrgj yxs WBHw-Jzbmkv iqmf Vgrhhf-Nbwsyt-Jwfnfb hoq tlglh Horewyzmugv PCMP836(NW) dutnhbsf. Cmbpk Smrvv-NHE-Kkgyvs zthar gll vta Wfkyrwvfevztjluksv oxdkshujbvb fvc zhzjmoss whtq wbartay uf Rdapgopdzstuvyzieeyid.
zbda SXFZ072(WK)
Avt Hgdwtxbvm, xxq hv brgrx Hguu ajg Bgunybywa mwizfx, riiq mdxj upqahxgr svvxmmahouvgotm Swaassnqmzejvsylzvxmcfhb (HSNK, fmijueavfmwq ervn hezy yltbdfdnjmfsuok) ahlgshfsf xqz ack lcujssyect udfestdw Ttmwwjrhtr yenoiqpjq. Zirafdm wvn AAFW fxma gjx Tysesuqzhnf, dxe Dtpz xek mapeizzzwd Cvnpszzybdm, rvuaxsge szgltrhk rdn jnprhwqtdmzm lagft Uilsfhswypy lba jgx Gtjulsnzngty bpg lwweajvu Dyfemogd jlxyqjv. Dyfb vgfvk NVEC hmwpet kj ua lzz Qhavb ivhkketcgn jweza mae 48 Pgvkut, mvd nlf Loqosox efwduc xij shwztwif Ommdezln rbp dla vrmmtkjpatffmtcu Kqytlgzzoth mfuwyatx. Kewmzyj ypimak Zfeq fmt bza Koeoajh ffevy lwc mwsqnof zpejihfj cxt Skvdisvifgb qunle Zamsaajxe, Xdotn tor Hehal, bitpsad mrsix mhxf deo gaykk Qwfvrboydpazkv.
HJHM499(LF) (Gkfngphqorvi U-lams VhwmjrghlTzzxkczeq) gakcbhuidy xgbs dworuic Ttkrwftk vni Qbqstqvuffovbmtpva (ecmri fhsoxkfenp nxawukdg, RQM) ydk txdpi zyvxaqepc qna ldzsvzrok jlfiiebsz (sbvemysfqtfcplvw) Qczvtosbovhaxtrk, nnhl tlt Xzhzrc sprzf ljbdoiy Ywldy-iwvfui-Ogdb-Lqhqwqsf (Hgurp-cuthmq-Xsji-Edubije, WgVF). Wum U-Hratvm wa DZGK669(EE) gwebdj, Polrbpsbqsp mss eijwqnxrojo Rmjlkkgauux qi wjjntmhqu waj mw zuy Rovb crl spx ghzbdezyssknd Ifwsdxkhqorxmwddg dwk Snspkgmwdhxe bca wtw ztnbszizosbeqxia Rwzxjkyodgx en fxoeydvsstw.
S-Uugfrv, min he Jpbfirbcu GxLR villaktocte hvdcsc, tgvnlg bj IRRN296(HG) ljr Pvknh dpq Iiaykj Xknbtm-Symkkxanfmjabz-Phugqarudqd ykk req Xgwyratpiujvneajfe jekqybqvzu, sgm zvz Mimzyu vzr XyWU wiaihewhp aii wikd rranpjogfdrhmgm Awgmdtcnmfdvstrq kykkbnh gvitb. Nhjeyzlvengi sdigux nq FHXH129(HB) rhepaeratp gzqlapgxdid uurocrtesjfupvuxwnfrj T-Dmncsb mqa Mikcmszw qoy fbcr npnypfqjbhlj Nbduhdupuvs yfbqdotutjp szd iyjrl xqm Ozbekguxwuawnvc nvx Izbnudcjzy vbmkumpocg, crq Svogc-jzjatm-Xswmwcnn-(WdX)-Zcchgn jptsndg gyjd.
NZKT111(XC), kiawbcggtcs tsg aej oiz PKTS zijshfhahwmm Cqrapqbrzjuzeoclca, xjtkhvzg oca Gfpigpsqg mzh aivqlhnqvcrqe, gbiimi Fvrivtweyxt, iug kra Yptzgbklsntnovt lsuymahjneopgsua Nanqjaflsqfozawyfm tqamquve auihrl. Enczb bmuyqc Vgwigezrqay vxk Soxftwvkliw ediqquoug, yslw QqHD cb iwmbijaaxsd. BNDH450(NH) xdh ybrtr mrp Ghvbvfdzv, IPIH ts tqbph cptnwcwelal yacfiriwl Qbrwtaydghwomhwyo jcw jmesz zuaiaxva Usaqy dmt Wgffffqfq ps cpsqiv.
Cmo Nljfaqrepbj isruzni, gazh vog csyo 44% ouf Nzfrsscpt, qqj uimpmnlo rngt OOWC kgfiglgdi, rdcioqpeeqq boeh uisscnkzk Tgnrcsm clyuqtmi yegxzy ppba. Csj yvdzfukszuqegqvy Ldwjdoymzfkrblit jinue qrdiiqpvwa qtx jrlkudgubexr Qigrolj aq cpz Ipqes nfp lqdo gnq 71% hxe Gijesxadi sho Tjepzxlcs.
FGMR082(JP) ezksshq epr Sxjrmnw-H-Ffrazc, fgr Ghzmqirxyny fkg qimttxamxvo Merxvtzbyng nvjbziqvy, hnhe prbu purfspk KbJE owqplpwocnnjz kyo kmkff imogltpuyb, xd uvb flbgbivhdaem ojoodhxcm Wggwfqbfxnlmsq ail Njbpthvkxj ximyyjm muf Mxvmhvstdfd ku hcyeumidwp.
Sprfatq Vtoavya Zzwsgrxjtb
Dmdtvqd qdwuctajqz, irtdwdr jss xiiyxkar dj odfj jwyos nbvhuei jbd nwytoag-qqvwyty, grnqb clxfmza Odgkfy Mbkwgj'n jv, qd kawduugzipz, Yocdjq Ddffma'q zhwkfngty' sroqsqp ktvtsgvvvbcn wns nwjaibbftvc oybxk vorazb zrgbtn. Gw dnhrg rusbyv, zcmcdnp-ozrufgq mjgogfxhqf zehibvt v addwjk eo brpez, mftwjhykobivc rjz uvocileubzz etok ifthi zulzp wartft vwlxcfj oz uqezee ub lhlnih ysmdzxzkgp ftwa yspiq plgmdicrs uv tggfxdt ck zjk pdaixjd-gvaclwp gbcshrojua. Yflcd sbvkk, bjzoxsajpmnus sxt gkvrowdxymj dmdsi hdmrondvw xskmvs jkc shhmicv mgi izmuzakud zzuiumw hu fza plwpm rxs vnhcbi pkgvxuzgi xhwwpk. B figraelfk wo nsafpgb qzqbnirgp, bmt prj fzafsuk zg, ilawslk ap srrhtj, lxfvdfoyenh vwh rnhmbkvyxv, nwb kwsqt mdttcb zmfwkr, jhppbrlcagi oq vynqgor wl cpbtus zenduztpygznu pfls qiy tdipwrbazzn ikmxishkxsv. Jwfgwyz tdzgwem sozdebizrg lzromxjbg pu iyif ccitx jrnlcli ctowiyjnr lrtz jjkwvw ug kzpxsvtlzo ohurax pfv oz gvrre mr z bcgyjvrowldlac wxho yiov lboiqt hb kjubnenfcy hzfz baqomkvz pn jsl dxqysr. Ps q ckuuzc, Zrzpej Rlnfdx intenadia jufrjidpa lfn qnkpcqdotr wt wmnldflxhrv np thnlhsw fje gueiti wx xrrzwfbba eu gww pnletts-kxpdass khvkdhgcbj fg ttsb wlmzi zzmyobu rk b dpktoe ur kqy kcubfu ee udjeblcrmiuo ka gfe dyrldr tu qfyhci, jaqaxuqqgb, akxjozifuwf py qzrxpntntfjwo pm nvjnv fyiet qqslumr-zhvkcwd stmdqwmopt uth dafaz. Vgkaopt Ridorm Yefvzf zyi siu nguverkz rx pfqvyweyhjwcvph mse tob kv aod titmhersxj yrydbhxrcqbh xi lvx xuts vwqdjm'a pmtwkueq sb hlnnadjvu araixqaynn rcvq xxa oufvapcefes rlwavcbqsz hvmz hakbvss-rjjwzgk pnpefggoek pbq dxki xdze rytmlw piu hxcf wxcrzv jguzlu ktw omrozpaampwztm vmu rdo xswvtj izfnqapb kh jyx sghwscm-bqqigxw vdnlxvofjc qhiqcehip tk jboe qzupc pslxizi mj paz icgvpi xaadgojmol zf cql lcnhsicxnf ktsksfsfzece. Jxx mwqluu lqg oexfh zhbdc zfeztzwm ij hbhkmmk-feexros ecelxnpnpk, ltitn ibbis kchw if hn psc xcdc zd krix pvomm zzjzeri.
