Medulloblastome sind die häufigsten bösartigen Hirntumoren bei Kindern. Im Gegensatz zu den meisten anderen Krebsarten weisen sie besonders wenige Mutationen in wachstumsfördernden Genen auf. Es war daher nicht klar, warum sie ein derart aggressives Wachstumsverhalten an den Tag legen. Wissenschaftler aus dem Deutschen Krebsforschungszentrum fanden nun gemeinsam mit einem internationalen Kollegenteam heraus, dass bei einer besonders bösartigen Gruppe der Medulloblastome die Krebsgene meist nicht verändert sind, sondern stärker oder schwächer abgelesen werden. Verantwortlich dafür sind bislang unbekannte Steuermechanismen: So kapert sich etwa ein Krebsgen fremde Verstärker.
Die Wissenschaftler veröffentlichten ihre Ergebnisse gleich in zwei Artikeln in der Zeitschrift Nature.
Die Wissenschaftler veröffentlichten ihre Ergebnisse gleich in zwei Artikeln in der Zeitschrift Nature.
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