82152 Planegg-Martinsried, de
4SC presents clinical data on 4SC-201 at two specialised conferences in Geneva and BostonPlanegg-Martinsried, )
Organising the first conference entitled 'Molecular Targets and Cancer Therapeutics' are the European Organisation for Research and Treatment of Cancer (EORTC), the National Cancer Institute (NCI) and the American Association for Cancer Research (AACR). This conference will take place from 21 to 24 October 2008 at the Geneva Palexpo in Geneva, Switzerland.
The second conference, 'HDAC Inhibitors', is being organised by the Cambridge Healthtech Institute and will take place on 22 and 23 October 2008 in the World Trade Centre in Boston.
During these two conferences, 4SC AG will present data on the safety, tolerability, pharmacokinetics and efficacy of the drug candidate 4SC-201 in the treatment of cancer patients from the phase I study.
4SC-201 is a substance from the class of the histone deacetylase (HDAC) inhibitors. It therefore concerns a drug candidate with which this clinical study had begun previously under the designation BYK408740.
This study, which is being conducted at the Royal Marsden Hospital in Sutton near London under the direction of Professor J. S. de Bono and which is nearing its conclusion, is primarily testing the safety and tolerability of 4SC-201.
Preclinical models have already shown 4SC-201 to have a very good safety profile and a highly efficacious anti-tumour activity. In comparison with other drug candidates also based on the inhibition of these HDAC enzymes, 4SC-201 shows in these models particularly good pharmacokinetic properties upon oral administration. Areas of application for the planned efficacy studies in clinical phase II trials will target various tumour diseases, for which there is great demand for treatment.
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