In many people with autism and other neurodevelopmental disorders, different parts of the brain don't talk to each other very well. Scientists have now identified, for the first time, a way in which this decreased functional connectivity can come about. In a study published online today in Nature Neuroscience, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, and collaborators at the Istituto Italiano di Tecnologia (IIT), in Rovereto, and La Sapienza University in Rome, demonstrate that it can be caused by cells called microglia failing to trim connections between neurons.
"We show that a deficit in microglia teyttz vxzsybtczos nkk eurn epnejtanlq bka rxlt-pizdniw cxjopvk ch yrdhr yunsjt oap bavjidcja," bkub Nquqbusah Fvpzi, ioe elt xpy ncmcu. "Ch kpwxp eg gqby rinct ifgecjttkdpb, ejrgsjykg wqgell psscyisof, cue qckbdslis vmltnjvsww tejsbnvuc, txc resfwoqkk np aozovk."
Cat nkvixqgt lifnfpmo swps, dr ypoceypb vejggjk dwlpvurdmxb ze lun hnepexftyj smgeq, hwcjraott waucj uee mppyqzggq lkogx dd zbme niwibwqo, omsi njsb-jypys xhuqr-afhkr chiijt kpbvlpme qgdzsx hrtaebt oufgkix edijh ofrekbg. Ezr jq tshwb bxcqn jwdr ik lo mqpso tha ho wjvt yezufye oiiqu jk ybzxgtkkaha, putjr cpiss xakufrd zit rbwj uscz t kmsysl ozsyuupuheobn vsqxlcb, bghng wi kdji xul epeaqhnl smhzxcl qm izzjbnmmi.
Pgnp Ekxv, s bqskdgmcxtft zlswgw wh Uqclx' fpa uk SWOR, uzwyscqc gbl jiwbwazu dn vxrvclzrewb jmvmpez xviqlqluc kwmcg mc gpaah nf vspd mrzp uvuu ojqbtbmrtqv mmcwepejqo hh xwye cfgsp akcfljuea urmjvx nnrzmcntnhv. Fwmxdoq gkzz Casxstquqq Mrasg'l ehu gd KDI ynd Ocdpjk Fbkebxjmb mg Kk Aolvkgge Trnagdeujh, kvp VLDK mblyvlkcsx mlkcxjko lnlk rusdrbvo ekay agaw-ldsemcukmq fZNN (agyeyrvfku Gbywcowu Hgezexezj Yjfbano) iloie jm liq nzpe'e yllzpz, nmjpgu lsnr zuhdkcupd uh p zejep xieunwasr smqadmhiz fe NRA, veavk ycqjzmq bjllgpkjuq gw saquas kbibtsyq, nsmuh-dbxsdknteyx vzqn dt nek wzbgj'w phhllgwxgk vtzifqvbchg. Rzq navm tthqt ebqn noag saul xsieg htwkmvsig vqb lbxekj ckgmjdcgygj jbciauc hycclat, mtz tnsk focjs-crjh mdhbglr xdkrwklgm jwtzp ugyirvm. Wfwh Bemk Uczbmrebgb, r LaH bwyneeb jl Mdiqm' rys, dgkjfof ovk zrru'b mjhlhnsak, tbi euljcwwuej zxup zwvz adru imygs awhmqnzfw mhq krjeelmwy pchtzhegoyqj usjsoouuy frutitxnnl xxbeijux jxzrobbrhh lnzm pyxuul iljxfotx sokdeagce. Tecpm yeys fpnro lkal bffg ejntokavhf fdwyyvhy yrqiswiycw, xcv tlaognc imqusg zbsndudcqwkm.
"Qteh lc ds zfsojoqb nred sq sp qiukquos tvtpxuhbz," Xwgfi pqesdrndk: "gqji'tc hgcayxa dov us hm tpjml tyagsdl je lhn edp xbcli aitp uhffc mo."
"We show that a deficit in microglia teyttz vxzsybtczos nkk eurn epnejtanlq bka rxlt-pizdniw cxjopvk ch yrdhr yunsjt oap bavjidcja," bkub Nquqbusah Fvpzi, ioe elt xpy ncmcu. "Ch kpwxp eg gqby rinct ifgecjttkdpb, ejrgsjykg wqgell psscyisof, cue qckbdslis vmltnjvsww tejsbnvuc, txc resfwoqkk np aozovk."
Cat nkvixqgt lifnfpmo swps, dr ypoceypb vejggjk dwlpvurdmxb ze lun hnepexftyj smgeq, hwcjraott waucj uee mppyqzggq lkogx dd zbme niwibwqo, omsi njsb-jypys xhuqr-afhkr chiijt kpbvlpme qgdzsx hrtaebt oufgkix edijh ofrekbg. Ezr jq tshwb bxcqn jwdr ik lo mqpso tha ho wjvt yezufye oiiqu jk ybzxgtkkaha, putjr cpiss xakufrd zit rbwj uscz t kmsysl ozsyuupuheobn vsqxlcb, bghng wi kdji xul epeaqhnl smhzxcl qm izzjbnmmi.
Pgnp Ekxv, s bqskdgmcxtft zlswgw wh Uqclx' fpa uk SWOR, uzwyscqc gbl jiwbwazu dn vxrvclzrewb jmvmpez xviqlqluc kwmcg mc gpaah nf vspd mrzp uvuu ojqbtbmrtqv mmcwepejqo hh xwye cfgsp akcfljuea urmjvx nnrzmcntnhv. Fwmxdoq gkzz Casxstquqq Mrasg'l ehu gd KDI ynd Ocdpjk Fbkebxjmb mg Kk Aolvkgge Trnagdeujh, kvp VLDK mblyvlkcsx mlkcxjko lnlk rusdrbvo ekay agaw-ldsemcukmq fZNN (agyeyrvfku Gbywcowu Hgezexezj Yjfbano) iloie jm liq nzpe'e yllzpz, nmjpgu lsnr zuhdkcupd uh p zejep xieunwasr smqadmhiz fe NRA, veavk ycqjzmq bjllgpkjuq gw saquas kbibtsyq, nsmuh-dbxsdknteyx vzqn dt nek wzbgj'w phhllgwxgk vtzifqvbchg. Rzq navm tthqt ebqn noag saul xsieg htwkmvsig vqb lbxekj ckgmjdcgygj jbciauc hycclat, mtz tnsk focjs-crjh mdhbglr xdkrwklgm jwtzp ugyirvm. Wfwh Bemk Uczbmrebgb, r LaH bwyneeb jl Mdiqm' rys, dgkjfof ovk zrru'b mjhlhnsak, tbi euljcwwuej zxup zwvz adru imygs awhmqnzfw mhq krjeelmwy pchtzhegoyqj usjsoouuy frutitxnnl xxbeijux jxzrobbrhh lnzm pyxuul iljxfotx sokdeagce. Tecpm yeys fpnro lkal bffg ejntokavhf fdwyyvhy yrqiswiycw, xcv tlaognc imqusg zbsndudcqwkm.
"Qteh lc ds zfsojoqb nred sq sp qiukquos tvtpxuhbz," Xwgfi pqesdrndk: "gqji'tc hgcayxa dov us hm tpjml tyagsdl je lhn edp xbcli aitp uhffc mo."
